Increasing Anticholinergic Burden is Associated With Social Vulnerability in the Oldest Old

Anticholinergic agents are frequently administered to older people with dementia, who are more likely to receive multiple drugs, including psychotropic agents, thus increasing their anticholinergic burden (AB). 1 Hukins D. Macleod U. Boland J. Identifying potentially inappropriate prescribing in older people with dementia: A systematic review. Eur J Clin Pharmacol. 2019; 75: 467-481 Crossref PubMed Scopus (21) Google Scholar The unfavorable cognitive, behavioral, and affective side effects of AB accelerate the trajectory to frailty. 2 Moulis F. Moulis G. Balardy L. et al. Exposure to atropinic drugs and frailty status. J Am Med Dir Assoc. 2015; 3: 253-257 Abstract Full Text Full Text PDF Scopus (35) Google Scholar