纳米载体
脂质体
小泡
纳米技术
线粒体
化学
药物输送
药理学
计算生物学
生物
材料科学
生物化学
膜
作者
Volkmar Weissig,Maria Lozoya,Nusem Yu,Gerard G. M. D’Souza
出处
期刊:Methods in molecular biology
日期:2021-01-01
卷期号:: 13-25
被引量:7
标识
DOI:10.1007/978-1-0716-1262-0_2
摘要
DQAsomes (dequalinium-based liposome-like vesicles) are the prototype for all mitochondria-targeted vesicular pharmaceutical nanocarrier systems. First described in 1998 in a paper which has been cited as of May 2020 over 150 times, DQAsomes have been successfully explored for the delivery of DNA and low-molecular weight molecules to mitochondria within living mammalian cells. Moreover, they also appear to have triggered the design and development of a large variety of similar mitochondria-targeted nanocarriers. Potential areas of application of DQAsomes and of related mitochondria-targeted pharmaceutical nanocarriers involve mitochondrial gene therapy, antioxidant and updated therapy as well as apoptosis-based anticancer chemotherapy. Here, detailed protocols for the preparation, characterization, and application of DQAsomes are given and most recent developments involving the design and use of DQAsome-related particles are highlighted and discussed.
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