Whole-remnant and maximum-voxel SPECT/CT dosimetry in 131 I-NaI treatments of differentiated thyroid cancer

剂量学 核医学 成像体模 吸收剂量 甲状腺 医学 体素 甲状腺癌 有效剂量(辐射) Spect成像 断层摄影术 放射科
作者
P. Mı́nguez,Glenn Flux,J Genollá,A. Delgado,E. Rodeño,Katarina Sjögreen Gleisner
出处
期刊:Medical Physics [Wiley]
卷期号:43 (10): 5279-5287 被引量:19
标识
DOI:10.1118/1.4961742
摘要

Purpose To investigate the possible differences between SPECT/CT based whole‐remnant and maximum‐voxel dosimetry in patients receiving radio‐iodine ablation treatment of differentiated thyroid cancer (DTC). Methods Eighteen DTC patients were administered 1.11 GBq of 131 I‐NaI after near‐total thyroidectomy and rhTSH stimulation. Two patients had two remnants, so in total dosimetry was performed for 20 sites. Three SPECT/CT scans were performed for each patient at 1, 2, and 3–7 days after administration. The activity, the remnant mass, and the maximum‐voxel activity were determined from these images and from a recovery‐coefficient curve derived from experimental phantom measurements. The cumulated activity was estimated using trapezoidal‐exponential integration. Finally, the absorbed dose was calculated using S ‐values for unit‐density spheres in whole‐remnant dosimetry and S ‐values for voxels in maximum‐voxel dosimetry. Results The mean absorbed dose obtained from whole‐remnant dosimetry was 40 Gy (range 2–176 Gy) and from maximum‐voxel dosimetry 34 Gy (range 2–145 Gy). For any given patient, the activity concentrations for each of the three time‐points were approximately the same for the two methods. The effective half‐lives varied ( R = 0.865), mainly due to discrepancies in estimation of the longer effective half‐lives. On average, absorbed doses obtained from whole‐remnant dosimetry were 1.2 ± 0.2 (1 SD) higher than for maximum‐voxel dosimetry, mainly due to differences in the S ‐values. The method‐related differences were however small in comparison to the wide range of absorbed doses obtained in patients. Conclusions Simple and consistent procedures for SPECT/CT based whole‐volume and maximum‐voxel dosimetry have been described, both based on experimentally determined recovery coefficients. Generally the results from the two approaches are consistent, although there is a small, systematic difference in the absorbed dose due to differences in the S ‐values, and some variability due to differences in the estimated effective half‐lives, especially when the effective half‐life is long. Irrespective of the method used, the patient absorbed doses obtained span over two orders of magnitude.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
RogerCqz完成签到 ,获得积分10
1秒前
2秒前
jiang发布了新的文献求助10
2秒前
圆锥香蕉应助科研通管家采纳,获得20
3秒前
怕黑半仙应助科研通管家采纳,获得10
3秒前
3秒前
圆锥香蕉应助科研通管家采纳,获得20
3秒前
科研通AI5应助科研通管家采纳,获得10
3秒前
3秒前
领导范儿应助科研通管家采纳,获得10
3秒前
4秒前
4秒前
Cml完成签到,获得积分10
5秒前
Liufgui应助牛文文采纳,获得10
6秒前
chun发布了新的文献求助10
7秒前
YI应助南兮采纳,获得10
7秒前
orixero应助颜云尔采纳,获得10
8秒前
anna发布了新的文献求助10
8秒前
YWang发布了新的文献求助10
11秒前
11秒前
NiNi完成签到,获得积分10
13秒前
悦耳寒松发布了新的文献求助10
13秒前
sijing发布了新的文献求助10
14秒前
7777完成签到,获得积分10
14秒前
求求了,让孩子毕业吧完成签到,获得积分10
15秒前
15秒前
18秒前
我是老大应助LiuJinhui采纳,获得10
19秒前
22秒前
量子星尘发布了新的文献求助10
22秒前
清久完成签到,获得积分10
23秒前
牛马码字员完成签到,获得积分10
23秒前
橙果果发布了新的文献求助20
24秒前
所所应助11采纳,获得10
24秒前
tt大耳朵完成签到,获得积分10
25秒前
25秒前
26秒前
枫之林发布了新的文献求助10
26秒前
辛俊辰发布了新的文献求助10
26秒前
xiao完成签到 ,获得积分10
26秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989069
求助须知:如何正确求助?哪些是违规求助? 3531351
关于积分的说明 11253589
捐赠科研通 3269939
什么是DOI,文献DOI怎么找? 1804851
邀请新用户注册赠送积分活动 882074
科研通“疑难数据库(出版商)”最低求助积分说明 809073