弗拉万
化学
弹性蛋白酶
立体化学
超氧化物
消炎药
生物化学
生物
药理学
酶
作者
Ping‐Chung Kuo,Hsin‐Yi Hung,Tsong‐Long Hwang,Wen-Ke Du,Hsiang-chih Ku,E-Jian Lee,Shih‐Huang Tai,Fu‐An Chen,Tian-Shung Wu
标识
DOI:10.1021/acs.jnatprod.7b00039
摘要
Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.
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