体内
纳米团簇
分泌物
纳米棒
纳米颗粒
生物物理学
材料科学
杯状细胞
胶体金
纳米技术
细胞生物学
化学
生物
生物化学
医学
上皮
病理
生物技术
作者
Yanlei Liu,Kunlu Liu,Meng Yang,Yue Han,Qian Zhang,João Conde,Yuming Yang,Gabriel Alfranca,Yuxia Wang,Lijun Ma,Yingge Zhang,Jie Song,Yun‐Xiang Pan,Jian Ni,Daxiang Cui
标识
DOI:10.1186/s11671-019-2908-z
摘要
Up to date, the way in which metal nanoparticles are cleared in vivo has yet to be elucidated well. Herein, we report a novel intestinal goblet cell-mediated in vivo clearance pathway to remove metal nanoparticles. Typical metal nanoparticles such as triangular silver nanoplates, magnetic nanoparticles, gold nanorods, and gold nanoclusters were selected as representative examples. These metal nanoparticles were prepared, characterized, and injected via tail vein into a mice model with common bile duct (CBD) ligation. The feces and urines were collected for 7 days to be followed by the sacrifice of the mice and collection of the intestinal and gastric tissues for further analysis. The results showed that all four selected metal nanoparticles were located inside the goblet cells (GCs) of the whole intestinal tissue and were excreted into the gut lumen through the secretion of intestinal GC. Moreover, triangular silver nanoplates and gold nanorods were located inside the gastric parietal cells (PCs). Importantly, nanoparticles did not cause obvious pathological changes in intestinal tissues. In this study, we confirmed that the blood corpuscles are involved in the GCs secretion pathway. Furthermore, we found that the secretion of nanoparticles from intestinal GCs and PCs is accelerated by diarrhea induced via Chinese herbs. In conclusion, metal nanoparticles such as triangular silver nanoplates, magnetic nanoparticles, gold nanorods, and gold nanoclusters can be cleaned away by intestinal GCs and PCs. This novel pathway of in vivo clearance of metal nanoparticles has a great potential for future applications such as new drug design and development, nanoparticle-based labeling and in vivo tracking, and biosafety evaluation of in vivo nanoparticles.
科研通智能强力驱动
Strongly Powered by AbleSci AI