A Scalable Synthesis of 6,19‐Dihydroxyandrostenedione

Abstract Starting from the commercially available 19‐hydroxyandrostenedione, a practical protocol for the preparation of 6,19‐dihydroxyandrostenedione is reported. This compound is a key intermediate for the synthesis of cyclocitrinols. With the stereospecific epoxidation and following isomerization to allylic alcohol as key steps, a six‐step procedure provided desired product in high yield. The sequence is easy to scale‐up without the need of laborious chromatography.