Palladium-Catalyzed Oxidative Carbonylation of Benzylic C–H Bonds via Nondirected C(sp3)–H Activation

A new strategy for generating benzylpalladium reactive species from toluenes via nondirected C(sp3)–H activation has been developed. This led to construction of an efficient Pd-catalyzed reaction protocol for the oxidative carboxylation of benzylic C–H bonds to form substituted 2-phenylacetic acid esters and derivatives from inexpensive, commercially available starting materials.