Integrative Multi-Omics Profiling in Human Decedents Receiving Genetically Modified Pig Hearts Reveals Early Immune-Cell Responses Indicative of Perioperative Cardiac Xenograft Dysfunction

Purpose: Recent advances in living and decedent human xenotransplantation using pig organs show promise for first-in-human trials. In 2022, two heart xenografts from 10-gene edited pigs were transplanted into 2 human decedents, primarily to evaluate hyper-acute antibody mediated rejection and function of the xenograft over 3 days.