A Homochiral Porous Organic Cage‐Polymer Membrane for Enantioselective Resolution

Abstract Membrane‐based enantioselective separation is a promising method for chiral resolution due to its low cost and high efficiency. However, scalable fabrication of chiral separation membranes displaying both high enantioselectivity and high flux of enantiomers is still a challenge. Here, the authors report the preparation of homochiral porous organic cage (Covalent cage 3 (CC3)‐ R )‐based enantioselective thin‐film‐composite membranes using polyamide (PA) as the matrix, where fully organic and solvent‐processable cage crystals have good compatibility with the polymer scaffold. The hierarchical CC3‐ R channels consist of chiral selective windows and inner cavities, leading to favorable chiral resolution and permeation of enantiomers; the CC3‐ R /PA composite membranes display an enantiomeric excess of 95.2% for R‐ (+)‐limonene over S‐ (−)‐limonene and a high flux of 99.9 mg h −1 m −2 . This work sheds light on the use of homochiral porous organic cages for preparing enantioselective membranes and demonstrates a new route for the development of next‐generation chiral separation membranes.