自愈水凝胶
抗菌活性
生物相容性
伤口愈合
材料科学
乙烯醇
溴化铵
金黄色葡萄球菌
抗生素
聚乙烯醇
微生物学
核化学
高分子化学
细菌
聚合物
化学
医学
生物
生物化学
肺表面活性物质
免疫学
复合材料
冶金
遗传学
作者
Zhen-Ning Zhang,Zhipeng Ni,Yudi Huang,Hua Zhang,Zhewei Hu,Di Ye,Y. Shen,Mengyan Jia,Kehang Shi,Zhu Guo-qiang,Jin He,Lichang Xu,Fushan Shi,Haojie Yu,Lenan Zhuang,Sheng Wang
标识
DOI:10.1021/acsami.3c06371
摘要
Currently, antibiotics are the most common treatment for bacterial infections in clinical practice. However, with the abuse of antibiotics and the emergence of drug-resistant bacteria, the use of antibiotics has faced an unprecedented challenge. It is imminent to develop nonantibiotic antimicrobial agents. Based on the cation-π structure of barnacle cement protein, a polyphosphazene-based polymer poly[(N,N-dimethylethylenediamine)-g-(N,N,N,N-dimethylaminoethyl p-ammonium bromide (ammonium bromide)-g-(N,N,N,N-dimethylaminoethyl acetate ethylammonium bromide)] (PZBA) with potential adhesion and inherent antibacterial properties was synthesized, and a series of injectable antibacterial adhesive hydrogels (PZBA-PVA) were prepared by cross-linking with poly(vinyl alcohol) (PVA). PZBA-PVA hydrogels showed good biocompatibility, and the antibacterial rate of the best-performed hydrogel reached 99.81 ± 0.04% and 98.80 ± 2.16% against Staphylococcus aureus and Escherichia coli within 0.5 h in vitro, respectively. In the infected wound model, the healing rate of the PZBA-PVA-treated group was significantly higher than that of the Tegaderm film group due to the fact that the hydrogel suppressed inflammatory responses and modulated the infiltration of immune cells. Moreover, the wound healing mechanism of the PZBA-PVA hydrogel was further evaluated by real-time polymerase chain reaction and total RNA sequencing. The results indicated that the process of hemostasis and tissue development was prompted and the inflammatory and immune responses were suppressed to accelerate wound healing. Overall, the PZBA-PVA hydrogel is shown to have the potential for infected wound healing application.
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