怀孕
同型半胱氨酸
医学
产科
妊娠期
妊娠高血压
妇科
内分泌学
生物
遗传学
作者
Linda Dodds,Deshayne B. Fell,Kent Dooley,B. Anthony Armson,Alexander C. Allen,B.A. Nassar,Sherry L. Perkins,K.S. Joseph
出处
期刊:Clinical Chemistry
[Oxford University Press]
日期:2007-12-10
卷期号:54 (2): 326-334
被引量:122
标识
DOI:10.1373/clinchem.2007.097469
摘要
Increased total homocysteine (tHcy) may be associated with placental-mediated adverse pregnancy outcomes, but few prospective studies have measured tHcy before pregnancy outcome. This study was undertaken to determine whether increased tHcy measured in early pregnancy is associated with pregnancy loss, gestational hypertension (GH), preeclampsia, or small for gestational age (SGA) infants.We conducted a prospective cohort study between 2002 and 2005. We measured tHcy and serum folate in blood samples from pregnant women (<20 weeks' gestation) and collected detailed pregnancy information through a questionnaire and medical record review.Of the 2119 women included in the study, 103 had a pregnancy loss, 115 had gestational hypertension, 65 had preeclampsia, and 129 had an SGA infant. Subjects with increased tHcy concentrations were at increased risk of pregnancy loss [relative risk (RR) 2.1, 95% CI 1.2-3.6] or preeclampsia (RR 2.7, 95% CI 1.4-5.0) than subjects with lower tHcy concentrations, but increased tHcy concentration was not associated with increased risk of developing GH or having an SGA infant.The finding of high tHcy in early pregnancy as a risk factor for pregnancy loss and preeclampsia is consistent with a hypothesis that increased tHcy results in abnormalities of the placental vasculature.
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