巨噬细胞
THP1细胞系
免疫系统
炎症
先天免疫系统
生物
免疫学
细胞培养
细胞生物学
体外
遗传学
作者
Pallav K. Sharma,Kaliyamurthi Venkatachalam,Ambika Binesh
出处
期刊:Anti-inflammatory & anti-allergy agents in medicinal chemistry
[Bentham Science]
日期:2024-04-26
卷期号:23
标识
DOI:10.2174/0118715230294413240415054610
摘要
Abstract: Over the years, researchers have endeavored to identify dependable and reproducible in vitro models for examining macrophage behavior under controlled conditions. The THP-1 cell line has become a significant and widely employed tool in macrophage research within these models. Originating from the peripheral blood of individuals with acute monocytic leuke-mia, this human monocytic cell line can undergo transformation into macrophage-like cells, closely mirroring primary human macrophages when exposed to stimulants. Macrophages play a vital role in the innate immune system, actively regulating inflammation, responding to infec-tions, and maintaining tissue homeostasis. A comprehensive understanding of macrophage bi-ology and function is crucial for gaining insights into immunological responses, tissue healing, and the pathogenesis of diseases such as viral infections, autoimmune disorders, and neoplastic conditions. This review aims to thoroughly evaluate and emphasize the extensive history of THP-1 cells as a model for macrophage research. Additionally, it will delve into the significance of THP-1 cells in advancing our comprehension of macrophage biology and their invaluable contributions to diverse scientific domains.
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