心理学
神经科学
意识的神经相关物
社会认知
优势(遗传学)
前额叶皮质
社会行为
生物神经网络
认知心理学
发展心理学
生物
认知
生物化学
基因
作者
Nancy R. Mack,Nadia N. Bouras,Wen‐Jun Gao
标识
DOI:10.1016/j.biopsych.2024.03.008
摘要
Abstract
The prefrontal cortex (PFC) is well known as the executive center of the brain, combining internal states and goals to execute purposeful behavior, including social actions. With the advancement of tools for monitoring and manipulating neural activity in rodents, substantial progress has been made in understanding the specific cell types and neural circuits within the PFC that are essential for processing social cues and influencing social behaviors. Furthermore, combining these tools with translationally-relevant behavioral paradigms has also provided novel insights into the PFC neural mechanisms that may contribute to social deficits in various psychiatric disorders. This review highlights findings from the past decade that have shed light on the PFC cell types and neural circuits that support social information processing and distinct aspects of social behavior, including social interactions, social memory, and social dominance. We also explore how the PFC contributes to social deficits in rodents induced by social isolation, social fear conditioning, and social status loss. These studies provide evidence that the PFC uses both overlapping and unique neural mechanisms to support distinct components of social cognition. Further, specific PFC neural mechanisms drive social deficits induced by different contexts.
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