坏死性下垂
巨噬细胞极化
溃疡性结肠炎
结肠炎
平衡
化学
巨噬细胞
细胞生物学
医学
病理
免疫学
生物
细胞凋亡
程序性细胞死亡
生物化学
疾病
体外
作者
Yujie Yao,Tong Xu,Xiaojing Li,Xu Shi,Hao Wu,Ziwei Zhang,Shiwen Xu
出处
期刊:Theranostics
[Ivyspring International Publisher]
日期:2024-01-01
卷期号:14 (15): 5903-5925
被引量:1
摘要
Macrophage polarization plays an important role in the inflammatory regulation of ulcerative colitis (UC). In this context, necroptosis is a type of cell death that regulates intestinal inflammation, and selenoprotein S (SelS) is a selenoprotein expressed in intestinal epithelial cells and macrophages that prevents intestinal inflammation. However, the underlying mechanisms of SelS in both cell types in regulating UC inflammatory responses remain unclear. Therefore, the direct effect of SelS deficiency on necroptosis in colonic epithelial cells (CECs) was investigated. In addition, whether SelS knockdown exacerbated intestinal inflammation by modulating macrophage polarization to promote necroptosis in CECs was assessed.
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