医学
危险系数
内科学
移植
国际预后积分系统
骨髓增生异常综合症
比例危险模型
胃肠病学
造血干细胞移植
肿瘤科
干细胞
血液学
置信区间
骨髓
生物
遗传学
作者
Yoshimitsu Shimomura,Sho Komukai,Tetsuhisa Kitamura,Takayoshi Tachibana,Shuhei Kurosawa,Hidehiro Itonaga,Shokichi Tsukamoto,Noriko Doki,Yuta Katayama,Ayumu Ito,Masashi Sawa,Yasunori Ueda,Hirohisa Nakamae,Yuichiro Nawa,Masatsugu Tanaka,Yasuyuki Arai,Shuichi Ota,Keisuke Kataoka,Tetsuya Nishida,Junya Kanda,Takahiro Fukuda,Yoshiko Atsuta,Ken Ishiyama
摘要
Allogeneic haematopoietic stem cell transplantation (HCT) is the curative treatment for myelodysplastic syndrome with a complex karyotype (CK-MDS). However, only a few studies have been limited to patients with CK-MDS undergoing allogeneic HCT. This study aimed to identify the risk factors for patients with CK-MDS undergoing allogeneic HCT. We included 691 patients with CK-MDS who received their first allogeneic HCT. The overall survival (OS) was the primary end-point, estimated using the Kaplan-Meier method. Prognostic factors were identified using a Cox proportional hazards model. The 3-year OS was 29.8% (95% confidence interval [CI]: 26.3-33.3). In the multivariable analysis, older age (hazard ratio [HR]: 1.44, 95% CI: 1.11-1.88), male sex (HR: 1.38, 95% CI: 1.11-1.71), poor haematopoietic cell transplant comorbidity index (HR: 1.47, 95% CI: 1.20-1.81), red blood cell transfusion requirement (HR: 1.58, 95% CI: 1.13-2.20), platelet transfusion requirement (HR: 1.85, 95% CI: 1.46-2.35), not-complete remission (HR: 1.55, 95% CI: 1.16-2.06), a high number of karyotype abnormality (HR: 1.63, 95% CI: 1.18-2.25) and monosomal karyotype (HR: 1.49, 95% CI: 1.05-2.12) were significantly associated with OS. Thus, the 3-year OS of allogeneic HCT was 29.8% in patients with CK-MDS, and we identified risk factors associated with poor OS.