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Efficacy of remote ischemic conditioning does not differ between men and women: A secondary analysis of the RICAMIS study

医学 置信区间 优势比 改良兰金量表 临床终点 逻辑回归 内科学 冲程(发动机) 血压 糖尿病 随机化 随机对照试验 物理疗法 缺血性中风 缺血 内分泌学 机械工程 工程类
作者
Huiling Qu,Xiao‐Yu Sun,Yu Cui,Yina Zhang,Dawei Chen
出处
期刊:European Journal of Neurology [Wiley]
卷期号:30 (7): 2022-2030 被引量:4
标识
DOI:10.1111/ene.15805
摘要

Abstract Background and Purpose The present study aimed to determine sex difference in clinical outcomes after Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke (RICAMIS). Methods In this secondary analysis of the RICAMIS study, eligible patients aged 18 years or older with acute moderate ischemic stroke who received remote ischemic conditioning (RIC) within 48 h of stroke onset were divided into two groups: men and women. The primary endpoint was an excellent functional outcome, defined as a modified Rankin Scale score of 0–1 at 90 days. Binary logistic regression analyses and generalized linear models were used. Results Of 1707 eligible patients, 34% (579) were women. Women had a higher burden of hypertension and diabetes, and less alcohol and smoking consumption than men. The mean systolic blood pressure and blood glucose level at randomization were higher in women than in men. Compared with the control group, RIC was associated with an increased rate of primary endpoint in men (unadjusted odds ratio [OR] = 1.277; 95% confidence interval [CI] 0.933–1.644; p = 0.057) and women (unadjusted OR = 1.454; 95% CI 1.040–2.032; p = 0.028). Furthermore, a higher absolute risk difference in primary endpoint between control and RIC groups was found in women (9.2%) than in men (5.7%), but there was no significant interaction effect between sex and intervention on primary outcome ( p interaction = 0.545). Conclusion Compared with men, women may have a higher probability of excellent functional outcomes at 90 days in the RIC group than in the control group; however, no interaction effect between sex and intervention was found.
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