Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study

孟德尔随机化 医学 溃疡性结肠炎 胃肠病学 内科学 番茄红素 克罗恩病 维生素D与神经学 抗氧化剂 疾病 基因型 生物 生物化学 基因 遗传变异
作者
Jie Chen,Xixian Ruan,Shuai Yuan,Minzi Deng,Han Zhang,Jing Sun,Lili Yu,Jack Satsangi,Susanna C. Larsson,Evropi Therdoratou,Xiaoyan Wang,Xue Li
出处
期刊:Alimentary Pharmacology & Therapeutics [Wiley]
卷期号:57 (4): 399-408 被引量:29
标识
DOI:10.1111/apt.17392
摘要

Summary Background Evidence for antioxidants, minerals and vitamins in relation to the risk of Crohn's disease (CD) and ulcerative colitis (UC) is limited and inconsistent. This mendelian randomization (MR) study aimed to examine the causal associations of circulating levels of antioxidants, minerals and vitamins with CD and UC. Methods Single‐nucleotide polymorphisms associated with antioxidants (beta‐carotene, lycopene and uric acid), minerals (copper, calcium, iron, magnesium, phosphorus, zinc and selenium), and vitamins (folate, vitamins A, B6, B12, C, D, E and K1) were employed as instrumental variables. Genetic associations with CD and UC were extracted from the UK Biobank, the FinnGen study and the International Inflammatory Bowel Disease Genetics Consortium. The inverse variance weighted method and sensitivity analyses were performed. Results Genetically predicted higher lycopene (OR = 0.94, 95% CI: 0.91–0.97), vitamins D (OR = 0.65, 95% CI: 0.54–0.79) and K1 (OR = 0.93, 95% CI: 0.90–0.97) levels were inversely associated with CD risk, whereas genetically predicted higher magnesium (OR = 1.53, 95% CI: 1.23–1.90) levels were positively associated with CD risk. Higher levels of genetically predicted lycopene (OR = 0.91, 95% CI: 0.88–0.95), phosphorus (OR = 0.69, 95% CI: 0.58–0.82), selenium (OR = 0.91, 95% CI: 0.85–0.97), zinc (OR = 0.91, 95% CI: 0.89–0.94), folate (OR = 0.71, 95% CI: 0.56–0.92) and vitamin E (OR = 0.78, 95% CI: 0.69–0.88) were associated with reduced UC risk, whereas genetically predicted high levels of calcium (OR = 1.46, 95% CI: 1.22–1.76) and magnesium (OR = 1.24, 95% CI: 1.03–1.49) were associated with increased risk of UC. Conclusions Our study provided evidence that circulating levels of antioxidants, minerals and vitamins might be causally linked to the development of IBD.
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