三氧化二砷
急性早幼粒细胞白血病
砷
化学
新陈代谢
糖尿病
碳水化合物代谢
内分泌学
内科学
药理学
医学
生物化学
维甲酸
基因
有机化学
作者
Mengliang Wu,Chunrong Pang,LU Sheng-wen,Thomas H. Hostetter,Xin Hai
标识
DOI:10.1016/j.etap.2023.104142
摘要
Our study aimed to explore whether type 2 diabetes (T2DM) can affect arsenic metabolism in acute promyelocytic leukemia (APL) patients treated with arsenic trioxide. We found that compared with non-diabetic APL patients, the concentrations of arsenic metabolites in APL patients with T2DM increased significantly and positively correlated with blood glucose (P < 0.05). Meanwhile, APL patients with T2DM were more prone to liver injury and QTc interval prolongation due to altered arsenic methylation capacity. Then we cultured HEK293T cells at different glucose concentrations, and the results showed that the cells with high glucose had higher concentrations of arsenic metabolites compared to other cells. Meanwhile, the high glucose significantly increased the mRNA and protein expression levels of the arsenic uptake transporter AQP7 in HEK293T cells. Overall, our study demonstrated that T2DM can lead to elevated concentrations of arsenic metabolites in APL patients by increasing AQP7 expression.
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