伏立康唑
马尔尼菲青霉菌
伊曲康唑
二型真菌
机会性感染
医学
医学微生物学
真菌病
毛霉病
免疫学
曲菌病
生物
皮肤病科
人类免疫缺陷病毒(HIV)
共感染
病理
抗真菌
病毒性疾病
酵母
遗传学
作者
Yunfei Li,Mimi Tang,Shusen Sun,Qin Hu,Sheng Deng
标识
DOI:10.1016/j.mycmed.2021.101214
摘要
Talaromyces (Penicillium) marneffei (T. marneffei) is an important pathogenic thermally dimorphic fungus in Southeast Asia that leads to a life-threatening systemic mycosis in immunodeficient hosts, especially in AIDS patients. With the increasing AIDS epidemic, the number of patients with T. marneffei infections in mainland China has increased rapidly in recent years. The infection can be life-threatening in people with immunodeficiencies, such as HIV, organ transplantations, autoimmune diseases, and malignant tumors. Here, we present a disseminated T. marneffei infection case in a renal transplant recipient successfully treated with voriconazole followed by itraconazole. We describe the patient's clinical progression from onset symptoms to recovery and review the additional 14 published cases with T. marneffei infections in renal transplant recipients. In addition, we discuss the route of infection and treatment strategies of T. marneffei. Our data suggest that patients with kidney transplantations in T. marneffei infection-endemic areas should presume the possibility of infection and initiate appropriate antifungal treatment.
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