Pharmacological treatment of attention-deficit hyperactivity disorder comorbid with an anxiety disorder

阿托莫西汀 哌醋甲酯 注意缺陷多动障碍 耐受性 焦虑 精神科 医学 随机对照试验 氟伏沙明 临床试验 梅德林 药物治疗 临床心理学 不利影响 内科学 氟西汀 政治学 血清素 法学 受体
作者
Camila B. Villas-Boas,Danielly Chierrito,Fernando Fernandez‐Llimós,Fernanda S. Tonin,Andréia Cristina Conegero Sanches
出处
期刊:International Clinical Psychopharmacology [Ovid Technologies (Wolters Kluwer)]
卷期号:34 (2): 57-64 被引量:8
标识
DOI:10.1097/yic.0000000000000243
摘要

The purpose of this study was to conduct a systematic review of the pharmacological options available to treat patients diagnosed with attention-deficit hyperactivity disorder and anxiety disorder, for generating evidence on the safest, most-effective and tolerable pharmacotherapy. To this end, a systematic search was performed in three electronic databases (Medline, Scopus and Directory of Open Access Journals; December 2017). Randomized, double-blind, parallel-design clinical trials evaluating the efficacy, safety or tolerability of therapies for attention-deficit hyperactivity disorder and anxiety disorder in children and adolescents or adults were considered. A total of 1960 articles were retrieved from the databases, of which five studies were included in the qualitative synthesis. Two of these studies evaluated the drug atomoxetine, another study evaluated desipramine, and the remaining two studies evaluated methylphenidate, with fluvoxamine being associated with methylphenidate in one of the trials. Owing to the high heterogeneity among studies, it was not possible to combine data for meta-analyses. Although only few studies have been evaluated in this systematic review, the results point to a more significant benefit of atomoxetine. This is probably because this drug was studied in a wider age range and evaluated by more specific scales for both disorders. To further strengthen this evidence, randomized, controlled and multicenter clinical trials with larger sample sizes should be conducted.
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