Colon capsule endoscopy: the evidence is piling up

We read with interest the multicentre comparison study by Cash et al on the diagnostic yield (DY) of colon capsule endoscopy (CCE) versus CT colonography (CTC) in a screening population.1 Out of 320 enrolled, data from 286 (89.4%) subjects were evaluated. CCE was superior to CTC in the detection of polyps ≥6 mm and non-inferior for polyps ≥10 mm. A recent meta-analysis2 of the use of CCE and CTC in patients with incomplete optical colonoscopy (OC) showed the DY of CTC at 10% (95% CI 7%–15%) and of CCE at 37% (95% CI 30%–43%) for any size polyp, suggesting the increased DY of CCE could outweigh its lower completion rate compared with the superiority of CTC there. Furthermore, a recent systematic review,3 including 2485 patients across 13 studies, confirmed that CCE is highly sensitive for clinically …