JAK/STAT – Emerging Players in Metabolism

贾纳斯激酶 STAT蛋白 JAK-STAT信号通路 斯达 生物 信号转导 车站3 STAT6 瘦素 激素 Janus激酶2 状态5 内分泌学 免疫系统 免疫学 细胞生物学 白细胞介素4 肥胖 酪氨酸激酶
作者
David W. Dodington,Harsh R. Desai,Minna Woo
出处
期刊:Trends in Endocrinology and Metabolism [Elsevier]
卷期号:29 (1): 55-65 被引量:185
标识
DOI:10.1016/j.tem.2017.11.001
摘要

The JAK/STAT signaling pathway serves as an important downstream mediator for a variety of cytokines, hormones, and growth factors. Emerging data show that this pathway is dysregulated in metabolic diseases including obesity and type 2 diabetes. With the use of tissue-specific knockout mice, JAK/STAT signaling in the peripheral metabolic organs has been shown to regulate a multitude of metabolic processes including, but not limited to, glucose tolerance, insulin sensitivity, energy expenditure, and adiposity. JAK/STAT signaling within immune cells crucially regulates inflammation that is associated with metabolic abnormalities including insulin resistance and obesity. The JAK/STAT signaling pathway is a promising therapeutic target for the treatment of obesity, metabolic syndrome, and diabetes. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial for transducing signals from a variety of metabolically relevant hormones and cytokines including growth hormone, leptin, erythropoietin, IL4, IL6 and IFNγ. A growing body of evidence suggests that this pathway is dysregulated in the context of obesity and metabolic disease. Recent development of animal models has been instrumental in identifying the role of JAK/STAT signaling in the peripheral metabolic organs including adipose, liver, muscle, pancreas, and the immune system. In this review we summarize current knowledge about the function of JAK/STAT proteins in the regulation of metabolism, and highlight new potential therapeutic targets for the treatment of obesity and diabetes. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial for transducing signals from a variety of metabolically relevant hormones and cytokines including growth hormone, leptin, erythropoietin, IL4, IL6 and IFNγ. A growing body of evidence suggests that this pathway is dysregulated in the context of obesity and metabolic disease. Recent development of animal models has been instrumental in identifying the role of JAK/STAT signaling in the peripheral metabolic organs including adipose, liver, muscle, pancreas, and the immune system. In this review we summarize current knowledge about the function of JAK/STAT proteins in the regulation of metabolism, and highlight new potential therapeutic targets for the treatment of obesity and diabetes. exocrine cells of the pancreas which produce enzymes that assist in the digestion of food. a hormone secreted by adipose tissue that regulates energy homeostasis. a carrier protein for fatty acids that is expressed primarily in adipocytes and macrophages. a type of adipose tissue that functions to convert chemical energy into heat. a cell within the pancreatic islet that produces, stores, and secretes the hormone insulin. a protein that promotes neurotransmitter synthesis and neurite outgrowth. a mitogenic factor for cell growth, proliferation, and differentiation. a hormone produced by the kidney that promotes the formation of red blood cells by the bone marrow. impaired ability to properly dispose glucose, leading to elevated levels in circulation. a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates. a hormone that stimulates cell growth, proliferation and regeneration. a hormone with a similar structure to insulin that functions in growth, development, and metabolism. a pathological condition in which cells fail to respond physiologically to insulin. a cytokine involved in the immune response and inflammation. a cytokine involved in the immune response and inflammation. a hormone predominantly made by adipose tissue that regulates energy balance. a cluster of conditions that increase the risk of cardiovascular disease including central abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low high-density lipoprotein (HDL) levels. a type of chronic leukemia in which extensive scarring in the bone marrow disrupts normal production of blood cells. Activating JAK2 mutations are found in this condition. a strain of mice that develop spontaneous autoimmune pancreatic β-cell destruction that is used as a model of type 1 diabetes. a transcription factor necessary for pancreatic development. a group of transcription factors that regulate genes important for development and metabolism. a hormone secreted by the pituitary gland that promotes lactation. DNA sequence that regulates the expression of insulin in rats and mice. intracellular transcription factors that are primarily activated by membrane receptor-associated Janus kinases (JAKs). the abnormal retention of lipids within a cell. a type of immune cell that plays a role in the adaptive immune system. a transport protein, synthesized by the liver, that carries the thyroid hormone thyroxine and retinol-binding protein. a mitochondrial inner membrane protein that is responsible for converting energy to heat instead of ATP. the major site of energy storage in the form of fat, contributes to endocrine regulation of energy balance.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
笨笨洙关注了科研通微信公众号
2秒前
思源应助顶顶小明采纳,获得10
2秒前
2秒前
科研通AI2S应助三三四采纳,获得10
6秒前
7秒前
7秒前
菜菜子完成签到,获得积分20
9秒前
JJ完成签到,获得积分20
11秒前
13秒前
顶顶小明完成签到,获得积分10
13秒前
元谷雪应助乐乐乐乐乐乐采纳,获得10
15秒前
笨笨洙发布了新的文献求助10
18秒前
20秒前
22秒前
Xiaoyan完成签到,获得积分10
27秒前
满意花卷完成签到 ,获得积分10
28秒前
Shanshan发布了新的文献求助150
28秒前
个性的振家完成签到,获得积分10
29秒前
zyfqpc应助dou采纳,获得20
33秒前
熊本熊完成签到,获得积分10
34秒前
34秒前
菜菜子留下了新的社区评论
34秒前
ljssll完成签到 ,获得积分10
34秒前
Crush完成签到,获得积分10
39秒前
xxxidgkris应助xiaowu采纳,获得10
44秒前
46秒前
斯文败类应助科研通管家采纳,获得10
49秒前
科研通AI2S应助科研通管家采纳,获得10
49秒前
科研通AI2S应助科研通管家采纳,获得10
49秒前
49秒前
NJY发布了新的文献求助10
51秒前
益智完成签到 ,获得积分10
51秒前
打打应助笨笨的从阳SJW采纳,获得10
51秒前
研研研完成签到,获得积分10
51秒前
52秒前
54秒前
Uniibooy发布了新的文献求助20
54秒前
55秒前
59秒前
1分钟前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Handbook of Qualitative Cross-Cultural Research Methods 600
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3137561
求助须知:如何正确求助?哪些是违规求助? 2788520
关于积分的说明 7787276
捐赠科研通 2444861
什么是DOI,文献DOI怎么找? 1300093
科研通“疑难数据库(出版商)”最低求助积分说明 625796
版权声明 601023