JAK/STAT – Emerging Players in Metabolism

贾纳斯激酶 STAT蛋白 JAK-STAT信号通路 斯达 生物 信号转导 车站3 Janus激酶2 内分泌学 内科学 医学 细胞生物学 酪氨酸激酶
作者
David W. Dodington,Harsh R. Desai,Minna Woo
出处
期刊:Trends in Endocrinology and Metabolism [Elsevier BV]
卷期号:29 (1): 55-65 被引量:209
标识
DOI:10.1016/j.tem.2017.11.001
摘要

The JAK/STAT signaling pathway serves as an important downstream mediator for a variety of cytokines, hormones, and growth factors. Emerging data show that this pathway is dysregulated in metabolic diseases including obesity and type 2 diabetes. With the use of tissue-specific knockout mice, JAK/STAT signaling in the peripheral metabolic organs has been shown to regulate a multitude of metabolic processes including, but not limited to, glucose tolerance, insulin sensitivity, energy expenditure, and adiposity. JAK/STAT signaling within immune cells crucially regulates inflammation that is associated with metabolic abnormalities including insulin resistance and obesity. The JAK/STAT signaling pathway is a promising therapeutic target for the treatment of obesity, metabolic syndrome, and diabetes. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial for transducing signals from a variety of metabolically relevant hormones and cytokines including growth hormone, leptin, erythropoietin, IL4, IL6 and IFNγ. A growing body of evidence suggests that this pathway is dysregulated in the context of obesity and metabolic disease. Recent development of animal models has been instrumental in identifying the role of JAK/STAT signaling in the peripheral metabolic organs including adipose, liver, muscle, pancreas, and the immune system. In this review we summarize current knowledge about the function of JAK/STAT proteins in the regulation of metabolism, and highlight new potential therapeutic targets for the treatment of obesity and diabetes. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial for transducing signals from a variety of metabolically relevant hormones and cytokines including growth hormone, leptin, erythropoietin, IL4, IL6 and IFNγ. A growing body of evidence suggests that this pathway is dysregulated in the context of obesity and metabolic disease. Recent development of animal models has been instrumental in identifying the role of JAK/STAT signaling in the peripheral metabolic organs including adipose, liver, muscle, pancreas, and the immune system. In this review we summarize current knowledge about the function of JAK/STAT proteins in the regulation of metabolism, and highlight new potential therapeutic targets for the treatment of obesity and diabetes. exocrine cells of the pancreas which produce enzymes that assist in the digestion of food. a hormone secreted by adipose tissue that regulates energy homeostasis. a carrier protein for fatty acids that is expressed primarily in adipocytes and macrophages. a type of adipose tissue that functions to convert chemical energy into heat. a cell within the pancreatic islet that produces, stores, and secretes the hormone insulin. a protein that promotes neurotransmitter synthesis and neurite outgrowth. a mitogenic factor for cell growth, proliferation, and differentiation. a hormone produced by the kidney that promotes the formation of red blood cells by the bone marrow. impaired ability to properly dispose glucose, leading to elevated levels in circulation. a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates. a hormone that stimulates cell growth, proliferation and regeneration. a hormone with a similar structure to insulin that functions in growth, development, and metabolism. a pathological condition in which cells fail to respond physiologically to insulin. a cytokine involved in the immune response and inflammation. a cytokine involved in the immune response and inflammation. a hormone predominantly made by adipose tissue that regulates energy balance. a cluster of conditions that increase the risk of cardiovascular disease including central abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low high-density lipoprotein (HDL) levels. a type of chronic leukemia in which extensive scarring in the bone marrow disrupts normal production of blood cells. Activating JAK2 mutations are found in this condition. a strain of mice that develop spontaneous autoimmune pancreatic β-cell destruction that is used as a model of type 1 diabetes. a transcription factor necessary for pancreatic development. a group of transcription factors that regulate genes important for development and metabolism. a hormone secreted by the pituitary gland that promotes lactation. DNA sequence that regulates the expression of insulin in rats and mice. intracellular transcription factors that are primarily activated by membrane receptor-associated Janus kinases (JAKs). the abnormal retention of lipids within a cell. a type of immune cell that plays a role in the adaptive immune system. a transport protein, synthesized by the liver, that carries the thyroid hormone thyroxine and retinol-binding protein. a mitochondrial inner membrane protein that is responsible for converting energy to heat instead of ATP. the major site of energy storage in the form of fat, contributes to endocrine regulation of energy balance.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
FashionBoy应助潇湘雪月采纳,获得10
3秒前
传奇3应助leanne采纳,获得10
3秒前
大模型应助Heartlark采纳,获得10
5秒前
7秒前
moxi摩西完成签到,获得积分10
7秒前
卷卷完成签到,获得积分10
9秒前
时笙发布了新的文献求助10
10秒前
10秒前
pterion完成签到,获得积分10
10秒前
10秒前
12秒前
哒哒完成签到,获得积分10
14秒前
14秒前
循环发布了新的文献求助10
14秒前
幽默毛衣发布了新的文献求助10
17秒前
19秒前
循环完成签到,获得积分10
19秒前
leanne发布了新的文献求助10
19秒前
20秒前
量子星尘发布了新的文献求助10
20秒前
21秒前
21秒前
开灯人和关灯人完成签到,获得积分20
22秒前
Stardust发布了新的文献求助10
23秒前
24秒前
FashionBoy应助爱笑晓曼采纳,获得10
25秒前
张雯思发布了新的文献求助10
26秒前
Priority完成签到,获得积分10
27秒前
光热效应发布了新的文献求助30
27秒前
风之星给风之星的求助进行了留言
27秒前
27秒前
ASH发布了新的文献求助10
27秒前
OxO完成签到,获得积分10
27秒前
28秒前
搜集达人应助快乐一江采纳,获得10
28秒前
29秒前
leanne完成签到,获得积分20
30秒前
幽默毛衣完成签到,获得积分10
31秒前
晨曦完成签到,获得积分10
31秒前
延文星发布了新的文献求助10
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989390
求助须知:如何正确求助?哪些是违规求助? 3531487
关于积分的说明 11254109
捐赠科研通 3270153
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809174