人巨细胞病毒
免疫学
免疫系统
巨细胞病毒
延迟(音频)
发病机制
疾病
从长凳到床边
病毒
医学
病毒学
疱疹病毒科
生物
病毒性疾病
病理
计算机科学
电信
医学物理学
作者
Tania Crough,Rajiv Khanna
摘要
Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency and periodically reactivates without causing symptoms in healthy individuals. In the absence of an adequate host-derived immune response, this fine balance of permitting viral reactivation without causing pathogenesis is disrupted, and HCMV can subsequently cause invasive disease and an array of damaging indirect immunological effects. Over the last decade, our knowledge of the immune response to HCMV infection in healthy virus carriers and diseased individuals has allowed us to translate these findings to develop better diagnostic tools and therapeutic strategies. The application of these emerging technologies in the clinical setting is likely to provide opportunities for better management of patients with HCMV-associated diseases.
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