Synthesis of Heterocyclic Scaffolds via Prins, Oxonium-Ene and Related Cyclization Reactions

Abstract A variety of oxygen, nitrogen and sulfur heterocyclic compounds are synthesized via one-pot multicomponent Prins, aza-Prins, thia-Prins, oxonium-ene, iminium-ene and thionium-ene cyclization reactions. The reactions proceeds with high diastereo- and regioselectivity. Importantly, C–C, C–N, C–O and C–S bonds are formed in a singsle step. These procedures are extended for the synthesis of biologically active molecules and natural products. 1 Introduction 2 Prins Cyclization Reactions 3 Oxonium-Ene Cyclization Reactions 4 Conclusion