Effect of antiplatelet drugs on corrosion of 316L stainless steel for application to biomaterials

The corrosion of 316L stainless steel in simulated body fluid mixed with antiplatelet drugs was electrochemically investigated and characterized using near-edge X-ray absorption fine structure and X-ray photoelectron spectroscopies and metal-free ion chromatography associated with inductively coupled plasma–mass spectrometry. Commercial antiplatelet drug ions Ca2+, PO43−, SO42−, K+, Mg2+, and Cl− produced various passive films on the 316L surface. Hydroxyapatite combined with the highest inhibitory-layer Cr(III), Fe(II), and O2− concentrations provided the most efficient corrosion prevention. Results suggest that antiplatelet drugs are vital for anticoagulation and for preventing corrosion of devices implanted in patients during percutaneous coronary intervention.