重组
生物
谱系(遗传)
中国
病毒学
基因型
基因组
病毒
戊型肝炎病毒
遗传学
作者
Amina Nawal Bahoussi,Yan-Yan Guo,Pei-Hua Wang,Amina Dahdouh,Changxin Wu,Li Xing
摘要
Zoonotic hepatitis E, mainly caused by swine hepatitis E virus (sHEV), is endemic in China, causing great economic disruption and public health threats. Although recombination is critical for the evolution of viruses, there is a limited assessment of its occurrence among sHEVs. Herein, we analysed all available sHEV full-length genomes isolated in China during the past two decades (40 isolates) compared to 72 other sHEV strains isolated in different countries and determined that sHEV genotype 4 (sHEV4) dominates China. Eight potential natural recombination events were identified, four of which occurred in China and were mainly between sHEV4 strains, indicating the distinct character of China sHEV. One intergenotype recombination event was found in China, alarming the emergence of a new sHEV lineage that could become a critical threat to human health.
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