自愈水凝胶
角蛋白
合理设计
纳米技术
机械强度
材料科学
化学
生物物理学
生物
高分子化学
复合材料
古生物学
作者
Liling Chen,Run Meng,Rui Qing,Wenfeng Li,Ziwei Wang,Yao Hou,Jia Deng,Wei Pu,Zibin Gao,Bochu Wang,Shilei Hao
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-11-14
卷期号:22 (22): 8835-8844
被引量:16
标识
DOI:10.1021/acs.nanolett.2c02530
摘要
Although keratins are robust in nature, hydrogels producing their extracts exhibit poor mechanical properties due to the complicated composition and ineffective self-assembly. Here we report a bioinspired strategy to fabricate robust keratin hydrogels based on mechanism study through recombinant proteins. Homotypic and heterotypic self-assembly of selected type I and type II keratins in different combinations was conducted to identify crucial domain structures for the process, their kinetics, and relationship with the mechanical strength of hydrogels. Segments with best performance were isolated and used to construct novel assembling units. The new design outperformed combinations of native proteins in mechanical properties and in biomedical applications such as controlled drug release and skin regeneration. Our approach not only elucidated the critical structural domains and underlying mechanisms for keratin self-assembly but also opens an avenue toward the rational design of robust keratin hydrogels for biomedical applications.
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