[Toll-like receptors link atopic march and hygiene hypothesis].

The atopic march reveals that infants with atopic dermatitis are prone to food allergy, allergic rhinitis and asthma later in life. The hygiene hypothesis holds that the cleaner the personal hygiene and environment, the higher the incidence rate of asthma and allergy. It is believed that Toll like receptors (TLRs) are the bridge between innate immunity and adaptive immunity, playing an important role in inflammatory and immune diseases. More and more evidence shows that TLRs, involved in the pathophysiology of atopic march, connect atopic march with hygiene hypothesis as a potential therapeutic target for asthma and allergy.过敏进程揭示罹患特应性皮炎的婴幼儿后期易发生食物过敏、过敏性鼻炎和哮喘。卫生假说强调个人卫生和环境越干净，哮喘和变态反应（过敏症）的发病率反而越高。现认为，模式识别受体Toll样受体（TLR）是连接固有免疫和适应性免疫的桥梁，在炎症和免疫性疾病中起重要作用。越来越多的证据表明，TLR参与过敏进程的发生发展，并且连接过敏进程与卫生假说，有望成为治疗哮喘和过敏症的新靶标。.