高胰岛素血症
内分泌学
胰腺癌
内科学
高胰岛素血症
胰岛素
癌症
胰岛素受体
转分化
生物
糖尿病
胰腺
肥胖
癌症研究
医学
细胞
胰岛素抵抗
生物化学
作者
Ericka Vélez-Bonet,Kristyn Gumpper,Zobeida Cruz–Monserrate
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2023-12-14
卷期号:84 (3): 351-352
标识
DOI:10.1158/0008-5472.can-23-3932
摘要
Abstract Although there has been a long-standing connection between hyperinsulinemia and cancer development, there is a lack of understanding of the role of the insulin receptor on cells that can become cancerous. In a recent issue of Cell Metabolism, Zhang and colleagues, using a diet-induced obesity mouse model, identified a direct function of insulin receptors on pancreatic acinar cells expressing a KRASG12D mutation in promoting obesity-associated pancreatic cancer. Furthermore, insulin receptor signaling from hyperinsulinemia promoted the secretion of digestive enzymes that contributed to acinar to ductal metaplasia. These findings highlight an important connection between obesity, diabetes, and pancreatic tumor development and suggest potential strategies for obesity-associated cancer prevention targeting the insulin receptor signaling pathways.
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