A sensitive immunosensing platform based on the high cathodic photoelectrochemical activity of Zr-MOF and dual-signal amplification of peroxidase-mimetic Fe-MOF

阴极保护 过氧化物酶 化学 信号(编程语言) 金属有机骨架 组合化学 对偶(语法数字) 纳米技术 材料科学 电化学 电极 计算机科学 物理化学 有机化学 艺术 文学类 吸附 程序设计语言
作者
Cheng Zhong,Guangwen He,Rong Liu,Yueming Tan,Wenfang Deng
出处
期刊:Bioelectrochemistry [Elsevier]
卷期号:: 108677-108677
标识
DOI:10.1016/j.bioelechem.2024.108677
摘要

Cathodic photoelectrochemical (PEC) analysis has received special concerns because of its outstanding anti-interference capability toward reductive substances in samples, so it is highly desirable to develop high-performance photocathodic materials for PEC analysis. Herein, a Zr-based metal–organic framework (Zr-MOF), MOF-525, is explored as a photoactive material in aqueous solution for the first time, which shows a narrow band-gap of 1.82 eV, excellent visible-light absorption, and high cathodic PEC activity. A sandwiched-type PEC immunosensor for detecting prostate-specific antigen (PSA) is fabricated by using MIL-101-NH2(Fe) label and MOF-525 photoactive material. MIL-101-NH2(Fe) as a typical Fe-MOF can serve as a peroxidase mimic to catalyze the production of precipitates on the photoelectrode. Both the produced precipitates and the MIL-101-NH2(Fe) labels can quench the photocathodic current, enabling “signal-off” immunosensing of PSA. The detection limit is 3 fg mL−1, and the linear range is between 10 fg mL−1 and 100 ng mL−1 for detecting PSA. The present study not only develops a high-performance Zr-MOF photoactive material for cathodic PEC analysis but also constructs a sensitive PEC immunosensing platform based on the dual-signal amplification of peroxidase-mimetic Fe-MOF.
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