区域选择性
胺化
化学
原子经济
硅烷化
环戊烯酮
功能群
产量(工程)
组合化学
烯醇
硅醚
氧化磷酸化
有机化学
有机合成
催化作用
材料科学
生物化学
冶金
聚合物
作者
Bence B. Botlik,Martin Weber,Florian Ruepp,Kazuki Kawanaka,Patrick Finkelstein,Bill Morandi
标识
DOI:10.1002/anie.202408230
摘要
Herein we report the development of an oxidative amination process for the streamlined synthesis of pyridones from cyclopentenones. Cyclopentenone building blocks can undergo in situ silyl enol ether formation, followed by the introduction of a nitrogen atom into the carbon skeleton with successive aromatisation to yield pyridones. The reaction sequence is operationally simple, rapid, and carried out in one pot. The reaction proceeds under mild conditions, exhibits broad functional group tolerance, complete regioselectivity, and is well scalable. The developed method provides facile access to the synthesis of 15N‐labelled targets, industrially relevant pyridone products and their derivatives in a fast and efficient way.
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