Fabrication of natural microcapsule with intrinsic core–shell structure as building blocks for achieving source control of obesity

制作 芯(光纤) 壳体(结构) 自然(考古学) 控制(管理) 纳米技术 材料科学 计算机科学 复合材料 地质学 医学 人工智能 古生物学 替代医学 病理
作者
Dan Li,Liwen Sun,Lingjuan Shi,Ying Zhang,Jun Liu,Mingqing Qiu,Yanhong Ma,Nana Kou,Wanting Song,Le Zhuo,Yang Li,Yang Wang,Xiaodan Yan,Tiantian Ye,Shujun Wang
出处
期刊:Chemical Engineering Journal [Elsevier BV]
卷期号:493: 152585-152585
标识
DOI:10.1016/j.cej.2024.152585
摘要

Regulating oil absorption at the intestinal absorption site is a safe and effective strategy for controlling obesity. Nevertheless, all patients may experience adverse effects from medication, including lipase inhibitors. Herein, we report the preparation of natural core–shell sporopollenin microcapsules with the ultimate goal of solidifying lipids post-lipase inhibition, thus exploring a safe and effective strategy for controlling lipid absorption in obesity. Naturally occurring micro/nanoparticles provide an incredible array of potential sources for fabricating pharmaceutical microcapsule carriers. Natural pine pollen was treated with phosphoric acid to yield intact, clean, and monodisperse microcapsules. Their intrinsic core–shell structures can be harnessed as potential carriers for pharmaceutical microcapsules, ensuring their viability for large-scale production. This study proposes an innovative strategy for complementary source control of obesity utilizing natural core–shell sporopollenin microcapsules and lipase inhibitors. Natural pine pollen microcapsule carriers exhibit natural core–shell structures, tunable wetting properties, and excellent liquid absorption capabilities. Interestingly, as-prepared hydrophobic pine pollen microcapsules can be utilized for the solidification of liquid drugs. Moreover, their strong oil adsorption capability can solidify lipids in complex oil–water systems post-oral lipase inhibition. Derived from pine pollen, these natural microcapsule carriers can be produced on a large scale and boast the safety of being food-derived, making them promising candidates for essential components in obesity source control.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Ava应助狂野的大公猪采纳,获得10
1秒前
huk发布了新的文献求助10
1秒前
丘比特应助温迪采纳,获得30
1秒前
yy应助osmanthus采纳,获得10
2秒前
2秒前
sutie发布了新的文献求助10
3秒前
4秒前
善学以致用应助背后海亦采纳,获得10
4秒前
拼搏的绿旋完成签到,获得积分10
4秒前
YIWENNN发布了新的文献求助10
6秒前
游一完成签到,获得积分10
6秒前
科研通AI5应助huk采纳,获得10
7秒前
虚拟莫茗完成签到 ,获得积分10
8秒前
刻苦小丸子完成签到,获得积分10
10秒前
10秒前
健壮听露完成签到,获得积分10
10秒前
苗条大叔发布了新的文献求助10
11秒前
11秒前
WK发布了新的文献求助10
13秒前
充电宝应助Muze采纳,获得10
13秒前
13秒前
13秒前
FashionBoy应助婳嬨采纳,获得10
14秒前
心想事成组完成签到,获得积分10
15秒前
JamesPei应助中央戏精学院采纳,获得10
16秒前
16秒前
Lucas应助健壮听露采纳,获得10
16秒前
可爱的函函应助顺心冰岚采纳,获得10
16秒前
背后海亦发布了新的文献求助10
17秒前
19秒前
20秒前
20秒前
20秒前
呱呱大菠萝完成签到,获得积分10
21秒前
小蘑菇应助jjj采纳,获得10
23秒前
努力的混子完成签到,获得积分10
23秒前
蓦然回首发布了新的文献求助10
24秒前
yaya发布了新的文献求助10
24秒前
25秒前
树阴照水完成签到,获得积分10
26秒前
高分求助中
All the Birds of the World 4000
Production Logging: Theoretical and Interpretive Elements 3000
Animal Physiology 2000
Les Mantodea de Guyane Insecta, Polyneoptera 2000
Am Rande der Geschichte : mein Leben in China / Ruth Weiss 1500
CENTRAL BOOKS: A BRIEF HISTORY 1939 TO 1999 by Dave Cope 1000
Machine Learning Methods in Geoscience 1000
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3741065
求助须知:如何正确求助?哪些是违规求助? 3283833
关于积分的说明 10037107
捐赠科研通 3000659
什么是DOI,文献DOI怎么找? 1646647
邀请新用户注册赠送积分活动 783804
科研通“疑难数据库(出版商)”最低求助积分说明 750427