免疫系统
先天免疫系统
生物
HMGB1
免疫学
模式识别受体
病毒病机
潮湿
病毒进入
免疫
病毒学
炎症
病毒
病毒复制
物理
气象学
作者
Huizhen Tian,Qiong Liu,Xiaomin Yu,Yanli Cao,Xiaotian Huang
标识
DOI:10.1080/1040841x.2024.2384885
摘要
Frequent viral infections leading to infectious disease outbreaks have become a significant global health concern. Fully elucidating the molecular mechanisms of the immune response against viral infections is crucial for epidemic prevention and control. The innate immune response, the host's primary defense against viral infection, plays a pivotal role and has become a breakthrough in research mechanisms. A component of the innate immune system, damage-associated molecular patterns (DAMPs) are involved in inducing inflammatory responses to viral infections. Numerous DAMPs are released from virally infected cells, activating downstream signaling pathways via internal and external receptors on immune cells. This activation triggers immune responses and helps regulate viral host invasion. This review examines the immune regulatory mechanisms of various DAMPs, such as the S100 protein family, high mobility group box 1 (HMGB1), and heat shock proteins, in various viral infections to provide a theoretical basis for designing novel antiviral drugs.
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