移植物抗宿主病
耐火材料（行星科学）
寄主（生物学）
医学
疾病
慢性病
重症监护医学
内科学
生物
遗传学
天体生物学
作者
Daniel Wolff,Corey Cutler,Stephanie J. Lee,Iskra Pusic,Henrique Bittencourt,Jennifer White,Mehdi Hamadani,Sally Arai,Amandeep Salhotra,José Antonio Pérez‐Simón,Amin M. Alousi,Hannah Choe,Mi Kwon,Arancha Bermúdez,Inho Kim,Gèrard Socié,Saurabh Chhabra,Vedran Radojčić,Timothy E. O’Toole,Chuan Tian,Peter Ordentlich,Zachariah DeFilipp,Carrie L. Kitko
标识
DOI：10.1056/nejmoa2401537
摘要
Colony-stimulating factor 1 receptor (CSF1R)-dependent monocytes and macrophages are key mediators of chronic graft-versus-host disease (GVHD), a major long-term complication of allogeneic hematopoietic stem-cell transplantation. The CSF1R-blocking antibody axatilimab has shown promising clinical activity in chronic GVHD.
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