橙皮苷
橙皮素
经络
口服
化学
吸收(声学)
药理学
色谱法
代谢物
生物化学
医学
类黄酮
柚皮素
抗氧化剂
材料科学
替代医学
复合材料
病理
作者
Alexia M. Nectoux,Chizumi Abe,Shu-Wei Huang,Naoto Ohno,Junji Tabata,Yuji Miyata,Kazunari Tanaka,Takashi Tanaka,Haruo Yamamura,Toshiro Matsui
标识
DOI:10.1021/acs.jafc.9b03594
摘要
We investigated the absorption and metabolic behavior of hesperidin (hesperetin-7-O-rutinoside) in the blood system of Sprague-Dawley rats by liquid chromatography- and matrix-assisted laser desorption ionization mass spectrometries (LC-MS and MALDI-MS). After a single oral administration of hesperidin (10 mg/kg), which was expected to be absorbed in its degraded hesperetin form, we detected intact hesperidin in the portal vein blood (tmax, 2 h) for the first time. We successfully detected glucuronized hesperidin in the circulating bloodstream, while intact hesperidin had disappeared. Further MS analyses revealed that homoeriodictyol and eriodictyol conjugates were detected in both portal and circulating blood systems. This indicated that hesperidin and/or hesperetin are susceptible to methylation and demethylation during the intestinal membrane transport process. Sulfated and glucuronized metabolites were also detected in both blood systems. In conclusion, hesperidin can enter into the circulating bloodstream in its conjugated forms, together with the conjugated forms of hesperetin, homoeriodictyol, and/or eriodictyol.
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