医学
可视模拟标度
维生素D与神经学
肾脏疾病
内科学
维生素
打开标签
皮肤病科
不利影响
胃肠病学
外科
作者
Kyung Eun Jung,Yu Ri Woo,Joong Sun Lee,Jong Ho Shin,Jin Uk Jeong,Dae Won Koo,Ki Tae Bang
标识
DOI:10.1111/1346-8138.12895
摘要
Abstract Chronic kidney disease‐associated pruritus ( CKD ‐ aP ) is a troublesome symptom in patients with end‐stage renal disease ( ESRD ). Recently, vitamin D deficiency has been known to be one of the possible etiologic factors in CKD ‐ aP . However, limited data is available on whether topical vitamin D treatment is effective for relieving CKD ‐ aP . Therefore, the purpose of this study is to evaluate the effectiveness of topically vitamin D for CKD ‐ aP . Twenty‐three patients with CKD ‐ aP were enrolled in a single center, open‐label study. Patients were instructed to apply a topical vitamin D (calcipotriol) agent (Daivonex solution; LEO Pharma) or vehicle solution twice daily for a month. We assessed the efficacy and safety of topical vitamin D on CKD ‐ aP using clinical and dermoscopic photographs, and questionnaires including the validated modified pruritus assessment score ( VMPAS ) and visual analog scale ( VAS ) every 2 weeks. Dry dermoscopic findings showed significant improvement of scale (dryness) on the skin of topical vitamin D‐treated patients compared with those of the vehicle group. Both VMPAS and VAS were significantly decreased after 2 and 4 weeks of the topical vitamin D treatment compared with the vehicle, respectively ( P < 0.05). No significant side‐effects were observed. Topical vitamin D may be one of the safe and effective therapeutic candidates for CKD‐ aP .
科研通智能强力驱动
Strongly Powered by AbleSci AI