肿胀 的
自愈水凝胶
动力学
共单体
高分子化学
水解
共聚物
丙烯酸
材料科学
聚合物
偶氮苯
化学
有机化学
复合材料
量子力学
物理
作者
Emmanuel O. Akala,Pavla Kopečková,Jindřich Kopeček
出处
期刊:Biomaterials
[Elsevier]
日期:1998-06-01
卷期号:19 (11-12): 1037-1047
被引量:146
标识
DOI:10.1016/s0142-9612(98)00023-4
摘要
Novel pH-sensitive hydrogels were synthesized by copolymerization of N,N-dimethylacrylamide, tert.-butylacrylamide, acrylic acid, 4,4′-di(methacryloylamino)azobenzene, and N-alkanoyl, O-methacryloylhydroxylamines. The influence of the length (and consequently hydrophobicity) of the alkanoyl (propionyl, hexanoyl, and lauroyl), and its content in the hydrogel on the kinetics of swelling were investigated. Upon change in the pH from acidic to neutral, N-alkanoyl, O-acylhydroxylamine moieties were hydrolyzed. The rate of side-chain hydrolysis was dependent on the length of the alkyl and the content of the hydrolyzable comonomer in the network structure. Further, chemical control of kinetics of swelling was coupled to biophysical control of kinetics of swelling by synthesizing hydrogels containing two types of cross-linking agents, one hydrolyzable, the other enzymatically degradable. The kinetics of swelling of cross-linked polymers was compared with the kinetics of hydrolysis of N-alkanoyl, O-methacryloylhydroxylamine moieties incorporated into linear soluble copolymers of similar structures.
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