免疫系统
弗雷明翰心脏研究
生物年龄
公制(单位)
人口
老化
人口学
老年学
医学
免疫学
弗雷明翰风险评分
生物
生理学
内科学
疾病
经济
社会学
运营管理
作者
Ayelet Alpert,Yishai Pickman,Holden Maecker,Yael Rosenberg‐Hasson,Xuhuai Ji,Renaud Gaujoux,Hadas Rabani,Elina Starosvetsky,Ksenya Kveler,Steven Schaffert,David Furman,Oren Caspi,Uri Rosenschein,Purvesh Khatri,Cornelia L. Dekker,Holden T. Maecker,Mark M. Davis,Shai S. Shen-Orr
出处
期刊:Nature Medicine
[Springer Nature]
日期:2019-03-01
卷期号:25 (3): 487-495
被引量:338
标识
DOI:10.1038/s41591-019-0381-y
摘要
Immune responses generally decline with age. However, the dynamics of this process at the individual level have not been characterized, hindering quantification of an individual's immune age. Here, we use multiple 'omics' technologies to capture population- and individual-level changes in the human immune system of 135 healthy adult individuals of different ages sampled longitudinally over a nine-year period. We observed high inter-individual variability in the rates of change of cellular frequencies that was dictated by their baseline values, allowing identification of steady-state levels toward which a cell subset converged and the ordered convergence of multiple cell subsets toward an older adult homeostasis. These data form a high-dimensional trajectory of immune aging (IMM-AGE) that describes a person's immune status better than chronological age. We show that the IMM-AGE score predicted all-cause mortality beyond well-established risk factors in the Framingham Heart Study, establishing its potential use in clinics for identification of patients at risk.
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