果糖胺
蜂胶
医学
安慰剂
氧化应激
过氧化氢酶
随机对照试验
安慰剂对照研究
内科学
2型糖尿病
安慰剂组
胃肠病学
传统医学
双盲
内分泌学
糖尿病
替代医学
病理
作者
Sepideh Hesami,Sima Hashemipour,Mohammad Reza Shiri‐Shahsavar,Yaghob Koushan,Hossein Khadem Haghighian
出处
期刊:PubMed
日期:2019-01-01
卷期号:10 (1): 48-54
被引量:34
标识
DOI:10.22088/cjim.10.1.48
摘要
Hyperglycemia in diabetic people resulted in oxidative conditions. Propolis is the third most important component of bee products which has various functional properties such as anti-oxidant due to its components. The aim of this study was to evaluate the propolis effect on fructosamine level, the catalase activity, and the level of oxidized LDL changes in type 2 diabetic patients.In this double-blind, randomized controlled trial study, 62 type 2 diabetic patients, attending Endocrine clinic in Velayat Hospital (Qazvin, Iran) in 2017, were randomly assigned to one of intervention and placebo (n=31) groups. Participants in intervention group took propolis capsule (500 mg) 3 times a day and those in placebo group took placebo capsules for 8-week. Fructosamine level, catalase activity and the level of oxidized-LDL were measured at the baseline and at the end of the study. Statistical analysis was performed using SPSS software.At the end of the study, significant differences were seen within groups and in-between groups. In Propolis group compared to the placebo, fructosamine (p<0.05), and the level of oxidized LDL (p<0.05) decreased, and catalase activity (p<0.05) improved. However, there were no significant changes in the placebo group at the end of trial.Eight weeks intake of propolis as a supplement in type II diabetic patients could improve anti-oxidant defense and decline production of hyperglycemia induced products such as fructosamine.
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