益生菌
微生物群
透明度(行为)
晋升(国际象棋)
土生土长的
公共卫生
医学
肠道微生物群
生物
生物技术
生物信息学
政治学
计算机科学
生态学
政治
遗传学
护理部
法学
细菌
计算机安全
作者
Jotham Suez,Niv Zmora,Eran Segal,Eran Elinav
出处
期刊:Nature Medicine
[Springer Nature]
日期:2019-05-01
卷期号:25 (5): 716-729
被引量:854
标识
DOI:10.1038/s41591-019-0439-x
摘要
Consumption of over-the-counter probiotics for promotion of health and well-being has increased worldwide in recent years. However, although probiotic use has been greatly popularized among the general public, there are conflicting clinical results for many probiotic strains and formulations. Emerging insights from microbiome research enable an assessment of gut colonization by probiotics, strain-level activity, interactions with the indigenous microbiome, safety and impacts on the host, and allow the association of probiotics with physiological effects and potentially useful medical indications. In this Perspective, we highlight key advances, challenges and limitations in striving toward an unbiased interpretation of the large amount of data regarding over-the-counter probiotics, and propose avenues to improve the quality of evidence, transparency, public awareness and regulation of their use.
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