Preparation of Chitosan-Based Hemostatic Sponges by Supercritical Fluid Technology

海绵 材料科学 超临界流体 傅里叶变换红外光谱 扫描电子显微镜 壳聚糖 化学工程 多孔性 凝血时间 化学 凝结 有机化学 复合材料 心理学 植物 精神科 工程类 生物
作者
Hu-Fan Song,Ai-Zheng Chen,Shibin Wang,Youngnam Kang,Shi-Fu Ye,Yuangang Liu,Wenguo Wu
出处
期刊:Materials [MDPI AG]
卷期号:7 (4): 2459-2473 被引量:30
标识
DOI:10.3390/ma7042459
摘要

Using ammonium bicarbonate (AB) particles as a porogen, chitosan (CS)-based hemostatic porous sponges were prepared in supercritical carbon dioxide due to its low viscosity, small surface tension, and good compatibility with organic solvent. Fourier transform infrared spectroscopy (FTIR) spectra demonstrated that the chemical compositions of CS and poly-(methyl vinyl ether-co-maleic anhydride) (PVM/MA) were not altered during the phase inversion process. The morphology and structure of the sponge after the supercritical fluid (SCF) process were observed by scanning electron microscopy (SEM). The resulting hemostatic sponges showed a relatively high porosity (about 80%) with a controllable pore size ranging from 0.1 to 200 µm. The concentration of PVM/MA had no significant influence on the porosity of the sponges. Comparative experiments on biological assessment and hemostatic effect between the resulting sponges and Avitene® were also carried out. With the incorporation of PVM/MA into the CS-based sponges, the water absorption rate of the sponges increased significantly, and the CS-PVM/MA sponges showed a similar water absorption rate (about 90%) to that of Avitene®. The results of the whole blood clotting experiment and animal experiment also demonstrated that the clotting ability of the CS-PVM/MA sponges was similar to that of Avitene®. All these results elementarily verified that the sponges prepared in this study were suitable for hemostasis and demonstrated the feasibility of using SCF-assisted phase inversion technology to produce hemostatic porous sponges.
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