Synthesis of ω-fluorinated octanoic acid and its β-substituted derivatives

Abstract Simple syntheses are described for the ω-fluorinated analogs of octanoic acid and its β-substituted derivatives in which insertion of a methyl and dimethyl group, and oxygen substitution at the C-3 position are involved, employing nucleophilic displacement with fluoride ion of the tosylate functions in the later stage of synthesis. The synthetic procedures offer easy and convenient access to the corresponding 18 F-labeled analogs using the readily available [ 18 F]fluoride ion.