血凝素(流感)
病毒
病毒学
性感冒病毒属
病毒包膜
甲型流感病毒
金刚烷胺
微生物学
铅化合物
化学
奥司他韦
正粘病毒科
生物
体外
生物化学
2019年冠状病毒病(COVID-19)
医学
疾病
传染病(医学专业)
病理
作者
Xueqing Chen,Longlong Si,Dong Liu,Peter Proksch,Lihe Zhang,Demin Zhou,Wenhan Lin
标识
DOI:10.1016/j.ejmech.2015.02.006
摘要
A class of prenylated indole diketopiperazine alkaloids including 15 new compounds namely rubrumlines A-O obtained from marine-derived fungus Eurotium rubrum, were tested against influenza A/WSN/33 virus. Neoechinulin B (18) exerted potent inhibition against H1N1 virus infected in MDCK cells, and is able to inhibit a panel of influenza virus strains including amantadine- and oseltamivir-resistant clinical isolates. Mechanism of action studies indicated that neoechinulin B binds to influenza envelope hemagglutinin, disrupting its interaction with the sialic acid receptor and the attachment of viruses to host cells. In addition, neoechinulin B was still efficient in inhibiting influenza A/WSN/33 virus propagation even after a fifth passage. The high potency and broad-spectrum activities against influenza viruses with less drug resistance make neoechinulin B as a new lead for the development of potential inhibitor of influenza viruses.
科研通智能强力驱动
Strongly Powered by AbleSci AI