产热
生物
脂解
产热素
褐色脂肪组织
内分泌学
基础代谢率
表型
内科学
脂肪组织
遗传学
基因
医学
作者
Zhihong Zhou,Shen Yon Toh,Zhengming Chen,Ke Guo,Chee Peng Ng,Sathivel Ponniah,Sheng-Cai Lin,Wanjin Hong,Peng Li
出处
期刊:Nature Genetics
[Springer Nature]
日期:2003-08-08
卷期号:35 (1): 49-56
被引量:447
摘要
The thermogenic activity of brown adipose tissue (BAT), important for adaptive thermogenesis and energy expenditure, is mediated by the mitochondrial uncoupling protein1 (Ucp1) that uncouples ATP generation and dissipates the energy as heat. We show here that Cidea, a protein of unknown function sharing sequence similarity with the N-terminal region of DNA fragmentation factors Dffb and Dffa, is expressed at high levels in BAT. Cidea-null mice had higher metabolic rate, lipolysis in BAT and core body temperature when subjected to cold treatment. Notably, Cidea-null mice are lean and resistant to diet-induced obesity and diabetes. Furthermore, we provide evidence that the role of Cidea in regulating thermogenesis, lipolysis and obesity may be mediated in part through its direct suppression of Ucp1 activity. Our data thus indicate a role for Cidea in regulating energy balance and adiposity.
科研通智能强力驱动
Strongly Powered by AbleSci AI