Liquid chromatography-mass spectrometry method for discovering the metabolic markers to reveal the potential therapeutic effects of naringin on osteoporosis

化学 柚皮苷 代谢途径 质谱法 色谱法 代谢组学 新陈代谢 液相色谱-质谱法 生物化学 药理学 医学
作者
Yuanfeng Li,Jinyang Liu,Hongzheng Zhou,Juntong Liu,Xiaoying Xue,Longfei Wang,Shujun Ren
出处
期刊:Journal of Chromatography B [Elsevier BV]
卷期号:1194: 123170-123170 被引量:5
标识
DOI:10.1016/j.jchromb.2022.123170
摘要

The pharmacological effects and therapeutic targets of naringin (NG) against osteoporosis (OP) is still unclear. Liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) based non-targeted metabonomics has been used to explore the differentiated metabolites and potential biological pathways of NG in the pathological process of OP. Using network pharmacology analysis, the key protein targets of NG against OP were also screened. By the metabonomics analysis, a total of 33 differentiated metabolites in serum were discovered, of which 21 were significantly regulated by NG treatment. These metabolites majorly associated with to amino acid metabolism,polyunsaturated fatty acid metabolism, pyruvate metabolism and glycerophospholipidmetabolism. Using the network pharmacology prediction analysis, NG was related to the expression changes of 13 important protein targets. It showed that high-throughput metabonomics strategy integrated with network pharmacology could insight into molecular mechanisms of natural products.
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