静电纺丝
聚己内酯
纳米纤维
化学工程
杰纳斯
纳米颗粒
抗菌活性
润湿
接触角
材料科学
乙基纤维素
银纳米粒子
聚合物
纳米技术
化学
复合材料
生物
细菌
工程类
遗传学
作者
Menglong Wang,Deng‐Guang Yu,Gareth R. Williams,S. W. Annie Bligh
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2022-06-06
卷期号:14 (6): 1208-1208
被引量:32
标识
DOI:10.3390/pharmaceutics14061208
摘要
Side-by-side electrospinning is a powerful but challenging technology that can be used to prepare Janus nanofibers for various applications. In this work, cellulose acetate (CA) and polycaprolactone (PCL) were used as polymer carriers for silver nanoparticles (Ag NPs) and lavender oil (LO), respectively, processing these into two-compartment Janus fibers. A bespoke spinneret was used to facilitate the process and prevent the separation of the working fluids. The process of side-by-side electrospinning was recorded with a digital camera, and the morphology and internal structure of the products were characterized by electron microscopy. Clear two-compartment fibers are seen. X-ray diffraction patterns demonstrate silver nanoparticles have been successfully loaded on the CA side, and infrared spectroscopy indicates LO is dispersed on the PCL side. Wetting ability and antibacterial properties of the fibers suggested that PCL-LO//CA-Ag NPs formulation had strong antibacterial activity, performing better than fibers containing only one active component. The PCL-LO//CA-Ag NPs had a 20.08 ± 0.63 mm inhibition zone for E. coli and 19.75 ± 0.96 mm for S. aureus. All the fibers had water contact angels all around 120°, and hence, have suitable hydrophobicity to prevent water ingress into a wound site. Overall, the materials prepared in this work have considerable promise for wound healing applications.
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