免疫球蛋白超家族
抗体
免疫学
医学
受体
效应器
免疫系统
免疫球蛋白G
先天免疫系统
补体系统
促炎细胞因子
碎片结晶区
炎症
内科学
作者
Anja Lux,Susanne Aschermann,Markus Biburger,Falk Nimmerjahn
标识
DOI:10.1136/ard.2009.117101
摘要
Immunoglobulin G (IgG) molecules are a family of glycoproteins essential for defending the body against invading pathogens. The antibody constant domain is very potent in initiating proinflammatory pathways such as the activation of innate immune effector cells via cellular receptors specific for the antibody constant region (Fc receptors) and the activation of the complement pathway. During autoimmune disease the normally protective antimicrobial function of these molecules is targeted to healthy tissues often with disastrous consequences. Interestingly, one successful anti-inflammatory therapy for many autoimmune diseases is the infusion of high doses of IgG molecules, the so-called intravenous IgG therapy. How one class of molecules can have such opposing functions will be the major focus of this review.
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