Interplay among Different Fosfomycin Resistance Mechanisms in Klebsiella pneumoniae

The objectives of this study were to characterize the role of the uhpT , glpT , and fosA genes in fosfomycin resistance in Klebsiella pneumoniae and evaluate the use of sodium phosphonoformate (PPF) in combination with fosfomycin. Seven clinical isolates of K. pneumoniae and the reference strain (ATCC 700721) were used, and their genomes were sequenced. Δ uhpT , Δ glpT , and Δ fosA mutants were constructed from two isolates and K. pneumoniae ATCC 700721.