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Anti-inflammatory and antioxidant effects of astaxanthin following spinal cord injury in a rat animal model

氧化应激 医学 脊髓损伤 抗氧化剂 脊髓 药理学 神经病理性疼痛 炎症 麻醉 内科学 化学 生物化学 精神科
作者
Alireza Masoudi,Masoumeh Jorjani,Morteza Alizadeh,Solmaz Mirzamohammadi,Mola Mohammadi
出处
期刊:Brain Research Bulletin [Elsevier BV]
卷期号:177: 324-331 被引量:20
标识
DOI:10.1016/j.brainresbull.2021.10.014
摘要

Spinal cord injury (SCI) is a severely debilitating problem leading to substantial decrease in the quality of life. After spinal cord injury, inflammation and oxidative stress plays a key role in initiating the secondary injury cascades leading to progressive tissue degradation and extreme functional deficits. Given that the primary mechanical injuries to spinal cord are rarely repaired, the pharmacological interventions may improve the neurological outcomes caused by secondary injury. Astaxanthin (AST) is considered as a xanthophyll carotenoid with potent antioxidant and anti-inflammatory properties, which has various pharmacological activities. In the present study, we aimed to firstly assess the protective effect of AST, and then to define the AST mechanism of action on a rat model of SCI. Based on the results of von Frey test, AST treatment significantly alleviated the SCI-induced neuropathic pain compared with the control groups (P < 0.05). The expression analysis by western blot shows reduced expression levels of COX-2, TNF-α, IL-1β, and IL-6 following AST treatment (P < 0.05). The activity of antioxidant enzymes was evaluated using ELISA. Therefore, ELISA experiments showed a significant reduction in the level of oxidative stress in SCI rat following AST treatment (P < 0.05). Furthermore, histopathological evaluations revealed that myelinated white matter and motor neuron number were significantly preserved after treatment with AST (P < 0.05). In conclusion, our study shows that AST could improve SCI through anti-inflammatory and antioxidant effects which leads to decreased tissue damage and mechanical pain after SCI.

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