清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Health risks of neonicotinoids chronic exposure and its association with glucose metabolism: A case-control study in rural China

环境卫生 医学 泊松回归 人口 优势比 毒理 生物 内科学
作者
Lulu Wang,Cuicui Ma,Dandan Wei,Mian Wang,Qingqing Xu,Juan Wang,Song Yu,Shunqing Xu,Tao Jing,Chongjian Wang,Zhenxing Mao
出处
期刊:Environmental Pollution [Elsevier BV]
卷期号:334: 122213-122213 被引量:5
标识
DOI:10.1016/j.envpol.2023.122213
摘要

Since neonicotinoids (NNIs) are widely used around the world, they are extensively distributed in the environment and frequently occurred in humans. This study was conducted to assess the risk of NNIs residues in vegetables and fruits in Henan province, and evaluate the associations of NNIs single and mixed exposure with glucose metabolism, and further explore whether testosterone mediated these relationships in Henan rural population. The data of vegetables and fruits were collected from Henan Province in 2020–2021, and participants were drawn from the Henan Rural Cohort study. Hazard quotient (HQ) and hazard index (HI) were used to assess the risk of exposure to the individual and combined NNIs through vegetables or fruits intake. Relative potency factor (RPF) method was utilized to normalize each NNIs to imidacloprid (IMIRPF). Generalized linear models were used to explore the effects of each NNIs and IMIRPF on glucose metabolism. Weight quartile sum (WQS) regression and Bayesian kernel machine regression (BKMR) model were applied to estimate the effect of NNIs mixtures on glucose metabolism. Mediation analysis was employed to explore whether testosterone mediated these relationships. The HQs and HI in both vegetables and fruits were much lower than 1, which indicated that NNIs in vegetables and fruits were not expected to cause significant adverse effects. However, plasma natural logarithm nitenpyram (Ln_NIT), Ln_thiacloprid-amid (Ln_THD-A), and Ln_IMIeq were positively associated with type 2 diabetes mellitus (T2DM) (odds ratio (OR) (95% confidence interval (CI)): 1.12 (1.05, 1.19), 1.21 (1.10, 1.32), and 1.48 (1.22, 1.80)). Both WQS regression and BKMR models observed significantly positive associations between NNIs mixture exposure and T2DM. Testosterone partially mediated these associations among women (PE = 6.67%). These findings suggest that human NNIs exposure may impair glucose metabolism and could contribute to rising rates of T2DM, and it's necessary to regulate the use of pesticides in rural areas.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
11秒前
桥西小河完成签到 ,获得积分10
27秒前
34秒前
大医仁心完成签到 ,获得积分10
41秒前
Betty发布了新的文献求助10
51秒前
汉堡包应助Sinner采纳,获得10
59秒前
lilaccalla完成签到 ,获得积分10
1分钟前
1分钟前
lanxinge完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
Sinner发布了新的文献求助10
2分钟前
2分钟前
2分钟前
2分钟前
xhcccc发布了新的文献求助20
2分钟前
SciGPT应助跳跃的代曼采纳,获得10
2分钟前
Yolo完成签到 ,获得积分10
2分钟前
2分钟前
跳跃的代曼完成签到,获得积分10
2分钟前
3分钟前
xhcccc完成签到,获得积分10
3分钟前
白天亮完成签到,获得积分10
3分钟前
4分钟前
wujiwuhui完成签到 ,获得积分10
4分钟前
4分钟前
4分钟前
玛卡巴卡爱吃饭完成签到 ,获得积分10
5分钟前
Jasper应助科研通管家采纳,获得10
5分钟前
爆米花应助bju采纳,获得10
5分钟前
5分钟前
TOUHOUU完成签到 ,获得积分10
5分钟前
6分钟前
6分钟前
领导范儿应助科研通管家采纳,获得10
7分钟前
科研通AI2S应助科研通管家采纳,获得10
7分钟前
科研通AI2S应助科研通管家采纳,获得10
7分钟前
科研通AI5应助科研通管家采纳,获得10
7分钟前
沐浠完成签到 ,获得积分10
7分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513318
关于积分的说明 11167279
捐赠科研通 3248691
什么是DOI,文献DOI怎么找? 1794414
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804652